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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often characterized by a focus on the practical aspects of study design, such as the recruitment process and consent as well as adherence to the use of standard equipment.

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A pragmatic trial that uses different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity that is crucial for a pragmatic trial to be valid and lessen the chance of bias, is also necessary. However, too much heterogeneity can result in problems with the trial design.

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The goal of pragmatic trials is to replicate real-life situations and achieve maximum credibility externally. They are typically ordered by policymakers and practitioners to guide their decisions. They also provide a useful way to identify the cause-effect relationship between an intervention and its outcomes. However, they should not be used as a substitute for explanatory studies.

The pragmatism idea is controversial and there are concerns about whether pragmatic trials should replace explanatory tests or if they are an alternative to them. Schwartz and Lellouch1 made the distinction between explanation studies, which support the validity of a physiological or clinical hypothesis, as well as pragmatic trials that aid in policy and practice decision-making. They also proposed a framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the characteristics of a pragmatic trial which includes the recruitment process, the design and implementation of the intervention, 무료슬롯 프라그마틱 and monitoring.

The number of pragmatic trials is growing. A recent Medline search using the terms naturalistic and pragmatic, 프라그마틱 슬롯 추천 limited to randomized controlled trials (RCTs) produced 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.