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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are typically described by their focus on practical aspects of designing a study that include the recruitment process and consent, adhering and the use of routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and included participants from various geographical areas. This type of heterogeneity, that is crucial for pragmatic trials to be valid and lessen the chance of bias, is also necessary. However too much heterogeneity could result in problems with the design of the trial.

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Pragmatic trials seek to replicate real-life settings and achieve maximum external validity. Usually, they are requested by practitioners and 무료 프라그마틱 policymakers in order to inform their decisions. They can also be used to assess the causal relationship between an intervention and its results. However, they shouldn't be used in lieu for the use of explanation studies.

The pragmatism idea is controversial and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove the clinical or physiological hypothesis as well as pragmatic trials that inform the policy and practice of. They also suggested an approach to pragmatic trials, dubbed PRECIS.2 This tool attempted to define the features of a practical trial, including the recruitment process, 프라그마틱 정품확인 the design and implementation of the intervention, as well as monitoring.

The number of pragmatic trials is growing. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs), yielded 34 articles, as shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.